Comparison · Online TRT clinics
Search "best online TRT clinic" and these three names come back more than any others. They look similar in the marketing and run on genuinely different models. Underneath all three, the medication is the same compounded testosterone from the same handful of 503A pharmacies. What you're actually paying for is the service layer wrapped around it.
No affiliate links. No referral codes. No financial relationship with any of the three, as of 2026.
The three models
A flat monthly fee covers telehealth visits and provider access, and in some plans the medication. Labs are billed separately. The most polished onboarding of the three, and the least flexible protocols.
No membership fee. Labs and provider visits are billed as you use them, but the initial panel is the widest in the category and the most expensive to start.
Scheduled visits with a named, long-tenured provider. No membership fee. The widest protocol flexibility of the three, and the least polished patient app.
Head to head
| Metric | Hone Health The consumer brand | Marek Health The enthusiast brand | Defy Medical The clinic that happens to be online |
|---|---|---|---|
| Model | Bundled membership, flat monthly fee | À la carte with required minimums | Traditional practice, telehealth delivery |
| Headline price | $129-200/mo, labs and some meds extra | $450+ initial panel, no membership fee | $250-350 initial consult, no membership fee |
| Annual all-in (2026) | $1,800-2,500 | $1,200-2,000 | $1,400-2,200 |
| Provider | Contracted network, short protocol-driven visits | Functional/anti-aging leaning, longer visits, can request the same provider | Smaller stable roster, named provider, often a decade or more in the field |
| Initial labs | $300-400, billed separately | ~$450, widest panel in the category | $200-400 via LabCorp or Quest |
| Best for | Wants it handled end to end, will pay for the polish | Wants the deepest workup, comfortable being self-directed | Wants an ongoing named provider and protocol flexibility |
Figures as of 2026, drawn from each clinic's published pricing and reporting in the full article. None of the three is a bad choice. The right one depends on how much hand-holding you want and how much you want to pay for it.
How to choose
You want the experience handled end to end and would rather not think about it. Hone.
You want the deepest initial workup and you're willing to pay for it upfront. Marek.
You want a real, ongoing relationship with a named provider, not a rotating pool. Defy.
You want a real doctor who handles everything, not just TRT. A DPC physician, not any of the three.
Your needs are complicated enough that telehealth is not the right channel. An in-person provider.
There is no universally best clinic in this category. Each of the three does something specific well. The right choice is the one whose strengths map to what you actually need.
What none of them does
If low testosterone is downstream of sleep apnea, severe insulin resistance, or a pituitary issue, the online clinics will address the symptom. None of the three is structured to dig into the cause.
If you're on multiple medications for other conditions, the telehealth model isn't built to manage that complexity. A primary care physician who knows your full history is the safer call.
Obvious, but worth saying. Telehealth cannot palpate a thyroid, feel for testicular abnormalities, or do a physical exam.
For the men these limits apply to, none of the big three is the right door. The right door is a physician who can see you in person and think about the whole picture.
Go deeper
This page is the short version. The full article covers what each clinic does well, what it doesn't, and how to read the marketing for any clinic in this category, not just these three.
We write about this every couple of weeks: what the clinics change, what the labs show, what we'd pick. Get the newsletter and follow along.